Source: FDA, National Drug Code (US) Revision Year: 2020
The chemical name for lifitegrast is (S)2(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)3(3-(methylsulfonyl)phenyl)propanoic acid. The molecular formula of lifitegrast is C29H24Cl2N2O7S and its molecular weight is 615.5 g/mol.
The structural formula of lifitegrast is:
* Chiral center
Lifitegrast is a white to off-white powder, which is soluble in water.
Xiidra (lifitegrast ophthalmic solution) 5% is a lymphocyte function-associated antigen-1 (LFA-1) antagonist supplied as a sterile, clear, colorless to slightly brownish-yellow colored, isotonic solution of lifitegrast with a pH of 7.0-8.0, and an osmolality range of 200-330 mOsmol/kg.
Xiidra contains Active: lifitegrast 50 mg/mL; Inactives: sodium chloride, sodium phosphate dibasic anhydrous, sodium thiosulfate pentahydrate, and water for injection. Sodium hydroxide and/or hydrochloric acid (to adjust pH).
| Dosage Forms and Strengths |
|---|
|
Ophthalmic solution containing lifitegrast 50 mg/mL (5%). |
| How Supplied |
|---|
|
Xiidra (lifitegrast ophthalmic solution) 5% (50 mg/mL) is supplied in a foil pouch containing 5 low-density polyethylene 0.2 mL single-use containers. Carton of 60 single-use containers NDC 0078-0911-12 |
| Drug | Countries | |
|---|---|---|
| XIIDRA | Canada, United States |
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