Chemical formula: C₂₉H₂₄Cl₂N₂O₇S Molecular mass: 615.48 g/mol PubChem compound: 11965427
Lifitegrast is a lymphocyte function-associated antigen-1 (LFA-1) antagonist. It binds to the integrin LFA-1, a cell surface protein found on leukocytes and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). ICAM-1 may be overexpressed in corneal and conjunctival tissues in DED.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| S01XA25 | S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| XIIDRA Οphthalmic solution | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Lifitegrast is an active ingredient of these brands:
United States (US)Canada (CA)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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