Alprostadil

Chemical formula: C₂₀H₃₄O₅ Molecular mass: 354.487 g/mol PubChem compound: 5280723

Therapeutic indications

Alprostadil is indicated for:

Erectile dysfunction

Population group: men, only adults (18 years old or older)

Alprostadil is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Alprostadil may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1.25-40 μg

125-1000 μg

Temporary maintenance of patency of the ductus arteriosus until corrective or palliative surgery

Population group: only newborns (0 - 40 days old)

Alprostadil is indicated to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in infants who have congenital defects and who depend upon the patent ductus for survival. Such congenital heart defects include pulmonary atresia, pulmonary stenosis, tricuspid atresia, tetralogy of Fallot, interruption of the aortic arch, co-arctation of the aorta, aortic stenosis, aortic atresia, mitral atresia, or transposition of the great vessels with or without other defects.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.05-0.1 μg/kg/min

Contraindications

Alprostadil is contraindicated in the following cases:

Pregnancy

Lactation

Stenosis of urethra, severe hypospadias, curvature, balanitis, urethritis, angulation, cavernosal fibrosis, Peyronie's disease

at least one of

Urethral stenosis
Hypospadias
Congenital lateral curvature of penis
Balanitis
Urethritis
Penis bent
Fibrosis of corpus cavernosum
Induratio penis plastica

Sickle cell anaemia or trait, multiple myeloma, leukaemia, angulation, cavernosal fibrosis, Peyronie's disease

at least one of

Sickle cell anemia
Thrombocytosis
Erythrocytosis
Multiple myeloma (clinical)
Leukaemia
Venous thrombosis
Thrombosis of penile vein
Recurrent priapism

< Previous: Overview

Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.