Amitriptyline Other names: Amitriptyline hydrochloride

Chemical formula: C₂₀H₂₃N  Molecular mass: 277.403 g/mol  PubChem compound: 2160

Therapeutic indications

Amitriptyline is indicated for:

Major depressive disorder

Population group: only adults (18 - 65 years old)

Amitriptyline is indicated for the treatment of major depressive disorder in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Major depressive disorder

Population group: only elderly (65 years old or older)

Amitriptyline is indicated for the treatment of major depressive disorder.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Neuropathic pain, prophylactic treatment of chronic tension type headache and migraine

Population group: only adults (18 - 65 years old)

Amitriptyline is indicated for:

  • the treatment of neuropathic pain in adults
  • the prophylactic treatment of chronic tension type headache (CTTH) in adults
  • the prophylactic treatment of migraine in adults

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Neuropathic pain, prophylactic treatment of chronic tension type headache and migraine

Population group: only elderly (65 years old or older)

Amitriptyline is indicated for:

  • the treatment of neuropathic pain in adults
  • the prophylactic treatment of chronic tension type headache (CTTH) in adults
  • the prophylactic treatment of migraine in adults

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Nocturnal enuresis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Bed wetting

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Amitriptyline is contraindicated in the following cases:

Recent myocardial infarction

Recent myocardial infarction

Any degree of heart block or disorders of cardiac rhythm

Heart block

Coronary artery insufficiency

at least one of
Coronary artery atheroma
Stenotic coronary artery
Coronary artery stenosis

Monoamine oxidase inhibitors (MAOIs)

MAO inhibitors

Severe liver disease

Hepatic failure stage IV

Pregnancy

Pregnancy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2018: AMITRIPTYLINE Film-coated tablet
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