Chemical formula: C₂₅H₂₀N₄O₅ Molecular mass: 568.534 g/mol PubChem compound: 135409642
Azilsartan medoxomil is an orally active prodrug that is rapidly converted to the active moiety, azilsartan, which selectively antagonises the effects of angiotensin II by blocking its binding to the AT1 receptor in multiple tissues. Angiotensin II is the principal pressor agent of the RAAS, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09CA09 | Azilsartan medoxomil | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09C Angiotensin II antagonists, plain → C09CA Angiotensin II antagonists, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| EDARBI Tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| EDARBYCLOR Tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Azilsartan medoxomil is an active ingredient of these brands:
United States (US)
Austria (AT)Brazil (BR)
Canada (CA)
Croatia (HR)Germany (DE)Hong Kong (HK)
Ireland (IE)Japan (JP)Lithuania (LT)Poland (PL)Turkey (TR)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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