Belzutifan

Chemical formula: C₁₇H₁₂F₃NO₄S  Molecular mass: 383.044 g/mol  PubChem compound: 117947097

Therapeutic indications

Belzutifan is indicated for:

von Hippel-Lindau (VHL) disease-associated tumours

Population group: only adults (18 years old or older)

Belzutifan is indicated as monotherapy for the treatment of adult patients with von Hippel-Lindau disease who require therapy for associated, localised renal cell carcinoma (RCC), central nervous system (CNS) haemangioblastomas, or pancreatic neuroendocrine tumours (pNET), and for whom localised procedures are unsuitable.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Advanced clear cell renal cell carcinoma

Population group: only adults (18 years old or older)

Belzutifan is indicated as monotherapy for the treatment of adult patients with advanced clear cell renal cell carcinoma that progressed following two or more lines of therapy that included a PD-(L)1 inhibitor and at least two VEGF-targeted therapies.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Belzutifan is contraindicated in the following cases:

Lactation

Lactation

Pregnancy - von Hippel-Lindau (VHL) disease-associated tumours

Pregnancy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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