Source: FDA, National Drug Code (US) Revision Year: 2024
Belzutifan is an inhibitor of hypoxia-inducible factor-2α (HIF-2α). The chemical name of belzutifan is 3-[[(1S,2S,3R)-2,3-Difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluorobenzonitrile. The molecular formula is C17H12F3NO4S and the molecular weight is 383.34 Daltons.
The chemical structure is:
Belzutifan is a white to light brown powder that is soluble in acetonitrile, dimethoxyethane, and acetone, sparingly soluble in ethyl acetate, very slightly soluble in isopropanol and toluene, and insoluble in water.
WELIREG is supplied as blue, film-coated tablets for oral use containing 40 mg of belzutifan together with croscarmellose sodium, hypromellose acetate succinate, magnesium stearate, mannitol, microcrystalline cellulose, and silicon dioxide, as inactive ingredients. In addition, the film-coating contains FD&C Blue #2 aluminum lake, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide.
| Dosage Forms and Strengths |
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Tablets: 40 mg, blue, oval shaped, film-coated, debossed with “177” on one side and plain on the other side. |
| How Supplied |
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WELIREG tablets are supplied as 40 mg blue, oval shaped, film-coated, debossed with “177” on one side and plain on the other side, available in:
The bottle also contains two desiccant canisters. Do not eat. Manufactured for: Merck Sharp & Dohme LLC, Rahway, NJ 07065, USA |
| Drug | Countries | |
|---|---|---|
| WELIREG | Canada, Israel, United Kingdom, United States |
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