Benazepril

Chemical formula: C₂₄H₂₈N₂O₅  Molecular mass: 424.49 g/mol  PubChem compound: 5362124

Active ingredient description

Benazepril is a prodrug which, after hydrolysis to the active substance benazeprilat, inhibits the angiotensin-converting enzyme (ACE) and so blocks the conversion of angiotensin I to angiotensin II. This reduces all the effects mediated by angiotensin II – i.e. vasoconstriction and production of aldosterone, which promotes the reabsorption of sodium and water in the renal tubules – and elevates cardiac output.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C09AA07 Benazepril C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain
Discover more medicines within C09AA07

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LOTENSIN Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 86541-75-5
DrugBank Drug: DB00542
KEGG Drug: D07499
PubChem Compound: 5362124
RxNorm Ingredient: 18867
SNOMED-CT Concept: 372511001
Benazepril (substance)
UNII Identifier: UDM7Q7QWP8
BENAZEPRIL

Medicines

Benazepril is an active ingredient of these brands:

United States (US)

  • LOTENSIN as BENAZEPRIL HYDROCHLORIDE

  • (combination) LOTENSIN HCT as BENAZEPRIL HYDROCHLORIDE
  • (combination) LOTREL as BENAZEPRIL HYDROCHLORIDE

Brazil (BR)

  • BHENA as BENAZEPRIL HYDROCHLORIDE

  • (combination) PRESS PLUS as BENAZEPRIL HYDROCHLORIDE

France (FR)

  • CIBACENE as BENAZEPRIL HYDROCHLORIDE

  • (combination) CIBADREX as BENAZEPRIL HYDROCHLORIDE

Germany (DE)

  • CIBACEN as BENAZEPRIL HYDROCHLORIDE

  • (combination) BENAZEPLUS as BENAZEPRIL HYDROCHLORIDE
  • (combination) CIBADREX as BENAZEPRIL HYDROCHLORIDE

Italy (IT)

  • CIBACEN as BENAZEPRIL HYDROCHLORIDE
  • ZINADRIL as BENAZEPRIL HYDROCHLORIDE

  • (combination) CIBADREX as BENAZEPRIL HYDROCHLORIDE
  • (combination) ZINADIUR as BENAZEPRIL HYDROCHLORIDE

Japan (JP)

  • CIBACEN as BENAZEPRIL HYDROCHLORIDE

Netherlands (NL)

  • CIBACEN as BENAZEPRIL HYDROCHLORIDE

Poland (PL)

South Africa (ZA)

  • BREXACE as BENAZEPRIL HYDROCHLORIDE
  • CIBACE as BENAZEPRIL HYDROCHLORIDE
  • PETACE as BENAZEPRIL HYDROCHLORIDE

  • (combination) CIBADREX as BENAZEPRIL HYDROCHLORIDE

Spain (ES)

  • CIBACEN as BENAZEPRIL HYDROCHLORIDE

Turkey (TR)

  • CIBACEN as BENAZEPRIL HYDROCHLORIDE

  • (combination) CIBADREX as BENAZEPRIL HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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