Chemical formula: C₂₂H₁₉NO₄ Molecular mass: 361.391 g/mol PubChem compound: 2391
Bisacodyl is a locally acting laxative from the diphenylmethane derivatives group having a dual action. As a contact laxative, for which also antiresorptive hydragogue effects have been described, bisacodyl stimulates after hydrolysis in the large intestine, the mucosa of both the large intestine and of the rectum. Stimulation of the mucosa of the large intestine results in colonic peristalsis with promotion of accumulation of water, and consequently electrolytes, in the colonic lumen. This results in a stimulation of defecation, reduction of transit time and softening of the stool. Stimulation of the rectum causes increased motility and a feeling of rectal fullness. The rectal effect may help to restore the “call to stool” although its clinical relevance remains to be established.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A06AB02 | Bisacodyl | A Alimentary tract and metabolism → A06 Laxatives → A06A Laxatives → A06AB Contact laxatives |
| A06AG02 | Bisacodyl | A Alimentary tract and metabolism → A06 Laxatives → A06A Laxatives → A06AG Enemas |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DULCOLAX Gastro-resistant tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Bisacodyl is an active ingredient of these brands:
United States (US)Austria (AT)Brazil (BR)
Croatia (HR)Ecuador (EC)Estonia (EE)Finland (FI)Hong Kong (HK)Ireland (IE)Japan (JP)Mexico (MX)Netherlands (NL)New Zealand (NZ)
Poland (PL)Spain (ES)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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