Bleomycin

Chemical formula: C₅₅H₈₄N₁₇O₂₁S₃⁺ Molecular mass: 1,415.552 g/mol PubChem compound: 5360373

Therapeutic indications

Bleomycin is indicated for:

Squamous cell carcinoma (SCC) of the head and neck, cervix, external genitalia

Population group: only adults (18 years old or older)

at least one of

Squamous cell carcinoma of head and neck
Squamous cell carcinoma of cervix
Squamous cell carcinoma of anogenital area

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10,000-15,000 IU/m² once or twice a week every 3-4 weeks

10,000-15,000 IU/m² once or twice a week every 3-4 weeks

Testicular carcinoma (seminoma and non-seminoma)

Population group: men, only adults (18 years old or older)

Primary malignant neoplasm of testis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10,000-15,000 IU/m² once or twice a week every 3-4 weeks

10,000-15,000 IU/m² once or twice a week every 3-4 weeks

10,000-15,000 IU/m² once a day for 5-6 consecutive days every 3-4 weeks

Hodgkin's lymphoma

Population group: only adults (18 years old or older)

Hodgkin's disease (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5,000-15,000 IU/m² once or twice a week

5,000-15,000 IU/m² once or twice a week

Non-Hodgkin's lymphoma

Population group: only adults (18 years old or older)

Non-Hodgkin’s lymphoma of intermediate and high malignancy in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5,000-15,000 IU/m² once or twice a week

5,000-15,000 IU/m² once or twice a week

Malignant pleural effusion

Population group: only adults (18 years old or older)

Pleural effusion due to malignant neoplastic disease

For this indication, competent medicine agencies globally authorize below treatments (click for details):

60,000 IU

Contraindications

Bleomycin is contraindicated in the following cases:

Pulmonary infection, severely impaired lung function

at least one of

Pulmonary infection
† Pulmonary function studies abnormal
Decreased respiratory function
Lung function testing abnormal

Lactation

Lactation

Ataxia-telangiectasia

Ataxia-telangiectasia syndrome

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