Chemical formula: C₃₀H₃₄ClN₇O₁₀S₂ Molecular mass: 752.21 g/mol
Cefiderocol is a siderophore cephalosporin. In addition to passive diffusion through outer membrane porin channels, cefiderocol is able to bind to extracellular free iron via its siderophore side chain, allowing active transport into the periplasmic space of Gram-negative bacteria through siderophore uptake systems. Cefiderocol subsequently binds to penicillin binding proteins (PBPs), inhibiting bacterial peptidoglycan cell wall synthesis which leads to cell lysis and death.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J01DI04 | J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01D Other beta-lactam antibacterials → J01DI Other cephalosporins | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| FETROJA Powder for solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| FETCROJA Powder for concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Cefiderocol is an active ingredient of these brands:
United States (US)
Austria (AT)
Croatia (HR)
France (FR)
Ireland (IE)
Italy (IT)
Lithuania (LT)
Poland (PL)
Romania (RO)
Spain (ES)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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