Chemical formula: C₁₀H₁₁ClFN₅O₃ Molecular mass: 303.677 g/mol PubChem compound: 119182
Clofarabine is a purine nucleoside anti-metabolite. Its antitumour activity is believed to be due to 3 mechanisms. Clofarabine produces DNA polymerase inhibition resulting in termination of DNA chain elongation and/or DNA synthesis/repair and ribonucleotide reductase inhibition with reduction of cellular deoxynucleotide triphosphate (dNTP) pools. Clofarabine also produces disruption of mitochondrial membrane integrity with the release of cytochrome C and other proapoptotic factors leading to programmed cell death even in non-dividing lymphocytes.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BB06 | Clofarabine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BB Purine analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CLOLAR Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| EVOLTRA Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Clofarabine is an active ingredient of these brands:
United States (US)Canada (CA)Cyprus (CY)Finland (FI)Hong Kong (HK)Japan (JP)Netherlands (NL)Romania (RO)Singapore (SG)Spain (ES)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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