Clofarabine

Chemical formula: C₁₀H₁₁ClFN₅O₃  Molecular mass: 303.677 g/mol  PubChem compound: 119182

Therapeutic indications

Clofarabine is indicated for:

Acute lymphoblastic leukaemia (ALL)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of acute lymphoblastic leukaemia (ALL) in paediatric patients who have relapsed or are refractory after receiving at least two prior regimens and where there is no other treatment option anticipated to result in a durable response. Safety and efficacy have been assessed in studies of patients ≤21 years old at initial diagnosis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Clofarabine is contraindicated in the following cases:

Severe hepatic impairment

Hepatic failure stage IV

Lactation

Lactation

Severe renal insufficiency

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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