Clozapine

Chemical formula: C₁₈H₁₉ClN₄  Molecular mass: 326.823 g/mol  PubChem compound: 2818

Therapeutic indications

Clozapine is indicated for:

Treatment-resistant schizophrenia

Population group: only adults (18 years old or older)

Clozapine is indicated in treatment-resistant schizophrenic patients and in schizophrenia patients who have severe, untreatable neurological adverse reactions to other antipsychotic agents, including atypical antipsychotics.

Treatment resistance is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two different antipsychotic agents, including an atypical antipsychotic agent, prescribed for adequate duration.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Psychosis during the course of Parkinson's disease

Population group: only adults (18 years old or older)

Clozapine is also indicated in psychotic disorders occurring during the course of Parkinson’s disease, in cases where standard treatment has failed.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Clozapine is contraindicated in the following cases:

Paralytic ileus

Paralytic ileus

Hypersensitivity to clozapine

Clozapine allergy

Clozapine-induced agranulocytosis

Drug-induced neutropenia

Idiosyncratic granulocytopenia, agranulocytosis

Drug-induced neutropenia

Impaired bone marrow function

Bone marrow finding

Uncontrolled epilepsy

Epilepsy

Alcoholic psychosis, drug intoxication, comatose conditions

at least one of
† Alcohol-induced psychosis
Poisoning by drug AND/OR medicinal substance
Coma

Circulatory collapse, CNS depression

at least one of
Shock
Central nervous system depression

Severe renal disorders, severe cardiac disorders

at least one of
Kidney disease
Heart disease

Liver disease, hepatic failure

at least one of
Hepatopathy
Hepatic insufficiency

Alcohol

Bone marrow suppressants

at least one of
Carbamazepine
Chloramphenicol
Sulfonamides
Butylpyrazolidines
Penicillamine
Cytotoxic antibiotics and related substances

Get recommendations

Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

Ask the Reasoner

Related medicines

Summary of Product Characteristics (SPC) 2020: ZAPONEX Orodispersible tablet
Structured Product Labeling (SPL/PLR) 2020: CLOZARIL Tablet
< Previous: Overview
Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈