Chemical formula: C₁₁H₂₈ClN₅O Molecular mass: 281.198 g/mol PubChem compound: 62816
Ion exchange resin which lowers plasma cholesterol through binding with bile acids in the intestinal lumen.
Colestipol is not absorbed; its action is limited to the lumen of the gastro-intestinal tract, and it is passed in the faeces. It binds bile acids in the intestinal lumen and causes them to be excreted in the faeces together with the polymer. When the enterohepatic circulation of bile acids is interrupted, cholesterol conversion to bile acids is enhanced and plasma cholesterol levels are thereby lowered.
Both clinical and animal studies with colestipol have provided no evidence of drug related intestinal neospasms. Colestipol is not mutagenic in the Ames test.
Reproduction and teratologic studies in animals gave no evidence of drug toxicity in parents or offspring.
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