PubChem compound: 44384985
Collagenases are proteinases that hydrolyze collagen under physiological conditions. Collagenase clostridium histolyticum is comprised of a mixture of Class I (AUX-I) and Class II (AUX-II) clostridial collagenases in a defined mass ratio. Both collagenases effectively cleave interstitial collagen but at different sites on the molecule; additionally, they prefer different conformations (triple helical versus denatured or cleaved).
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D03BA02 | Clostridiopeptidase | D Dermatologicals → D03 Preparations for treatment of wounds and ulcers → D03B Enzymes → D03BA Proteolytic enzymes |
| M09AB02 | M Musculo-skeletal system → M09 Other drugs for disorders of the musculo-skeletal system → M09A Other drugs for disorders of the musculo-skeletal system → M09AB Enzymes | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| XIAPEX Powder and solvent for solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC | |
| COLLAGENASE SANTYL Ointment | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Collagenase is an active ingredient of these brands:
United States (US)Austria (AT)Brazil (BR)
Canada (CA)Ecuador (EC)Hong Kong (HK)
Ireland (IE)
Lithuania (LT)Mexico (MX)
Netherlands (NL)Poland (PL)
Singapore (SG)
Spain (ES)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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