Danaparoid interacts in the following cases:
Danaparoid sodium should be used with caution in patients with moderately impaired renal, function with impaired haemostasis, ulcerative lesions of the gastro-intestinal tract or other diseases which may lead to an increased danger of haemorrhage into a vital organ or site.
Danaparoid sodium should be used with caution in patients with moderately impaired liver function with impaired haemostasis, ulcerative lesions of the gastro-intestinal tract or other diseases which may lead to an increased danger of haemorrhage into a vital organ or site.
Danaparoid sodium has been used in over 60 pregnancies (starting during the first trimester in almost 50% of the pregnancies, the second trimester in approximately 20% of the pregnancies and the third trimester in 25% of the pregnancies. For a small number of patients the starting trimester is unknown). Overall, the use of danaparoid sodium was successful.
Animal studies have not demonstrated any teratogenic effect or placental transfer. In the few cases in which human umbilical cord blood was tested for the presence of anti-Xa activity, no activity was found.
Although danaparoid sodium has been used with success in a small number of pregnancies, the available information is still considered to be insufficient to assess whether deleterious effects may occur in pregnancy during the use of danaparoid sodium.
Caution should be exercised when prescribing to pregnant women. If alternative antithrombotic treatment is unacceptable for medical reasons (e.g. HIT patients) danaparoid sodium can be used.
In five cases in which breast milk samples were tested for anti-Xa activity, all showed no or negligible amounts of anti-Xa activity (which would be hydrolyzed in the infant’s stomach and rendered harmless).
Although the data are limited, if alternative antithrombotic treatment is unacceptable for medical reasons (e.g. HIT patients) danaparoid sodium can be used during lactation.
Danaparoid sodium is not known to have any effect on the ability to drive and use machines.
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