Chemical formula: C₁₉H₂₇N₃O₆ Molecular mass: 393.19 g/mol PubChem compound: 91617630
Daprodustat is indicated for the treatment of anemia due to chronic kidney disease. Daprodustat is a reversible inhibitor of HIF-PH1, PH2 and PH3 (IC50 in the low nM range). This activity results in the stabilization and nuclear accumulation of HIF-1α and HIF-2α transcription factors, leading to increased transcription of the HIF-responsive genes, including erythropoietin.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| B03XA07 | B Blood and blood forming organs → B03 Antianemic preparations → B03X Other antianemic preparations → B03XA Other antianemic preparations | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| JESDUVROQ Film coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Daprodustat is an active ingredient of these brands:
United States (US)Japan (JP)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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