Chemical formula: C₂₁H₁₅N₃O₄ Molecular mass: 373.362 g/mol PubChem compound: 5493381
Deferasirox is an orally active chelator that is highly selective for iron (III). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Deferasirox promotes excretion of iron, primarily in the faeces.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V03AC03 | Deferasirox | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AC Iron chelating agents |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| EXJADE Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| JADENU Film-coated tablet / Granules | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| EXJADE Granules in sachet | European Medicines Agency (EU) | MPI, EU: SmPC |
Deferasirox is an active ingredient of these brands:
Australia (AU)Austria (AT)Cyprus (CY)Estonia (EE)Finland (FI)France (FR)Ireland (IE)Italy (IT)Japan (JP)Lithuania (LT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Nigeria (NG)Spain (ES)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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