Chemical formula: C₁₃H₁₆N₂ Molecular mass: 200.28 g/mol PubChem compound: 5311068
Dexmedetomidine is a selective alpha-2 receptor agonist with a broad range of pharmacological properties. It has a sympatholytic effect through decrease of the release of noradrenaline in sympathetic nerve endings. The sedative effects are mediated through decreased firing of locus coeruleus, the predominant noradrenergic nucleus, situated in the brainstem.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N05CM18 | Dexmedetomidine | N Nervous system → N05 Psycholeptics → N05C Hypnotics and sedatives → N05CM Other hypnotics and sedatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PRECEDEX Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| DEXDOR Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Dexmedetomidine is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)Estonia (EE)
Finland (FI)
France (FR)
Hong Kong (HK)
Ireland (IE)
Japan (JP)
Lithuania (LT)
Mexico (MX)
Netherlands (NL)
New Zealand (NZ)
Poland (PL)
Singapore (SG)
South Africa (ZA)Spain (ES)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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