Dihydroergotamine

Chemical formula: C₃₃H₃₇N₅O₅  Molecular mass: 583.677 g/mol  PubChem compound: 10531

Therapeutic indications

Dihydroergotamine is indicated for:

Migraine

Population group: only adults (18 - 65 years old)

Acute treatment of migraine headaches with or without aura.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Cluster headache episodes

Population group: only adults (18 - 65 years old)

Episodic cluster headache

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Dihydroergotamine is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Disorders that could lead to vasoconstrictive reactions

at least one of
Coronary arteriosclerosis
Septic shock
Cerebral vasoconstriction syndrome
Raynaud's disease
Hypertension
Ischemic heart disease
Past history of myocardial infarction
Coronary artery spasm

Temporal arteritis

Temporal arteritis

Hemiplegic migraine, basilar migraine

at least one of
Hemiplegic migraine
Basilar migraine

Severe hepatic impairment

Hepatic failure stage IV

CYP3A4 inhibitors

CYP3A4 inhibitors

Vasoconstrictors

at least one of
Sympathomimetics
Nicotine
Smoker
Nicotine user

Severely impaired renal function

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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