Chemical formula: C₂₂H₂₆N₂O₄S Molecular mass: 414.518 g/mol PubChem compound: 39186
Diltiazem is a calcium antagonist. It restricts the slow channel entry of calcium into the cell and so reduces the liberation of calcium from stores in the sarcoplasmic reticulum. This results in a reduction of the amount of available intracellular calcium reducing myocardial oxygen consumption.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C05AE03 | C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AE Muscle relaxants | |
| C08DB01 | Diltiazem | C Cardiovascular system → C08 Calcium channel blockers → C08D Selective calcium channel blockers with direct cardiac effects → C08DB Benzothiazepine derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ADIZEM-XL Prolonged release capsule | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| TILDIEM Modified-release tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| TIAZAC Capsule, ectended release | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| CARDIZEM CD Extended-release capsule | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Diltiazem is an active ingredient of these brands:
United States (US)Albania (AL)
Australia (AU)
Brazil (BR)Croatia (HR)
Ecuador (EC)
Finland (FI)France (FR)
Germany (DE)
Hong Kong (HK)Ireland (IE)
Italy (IT)Japan (JP)
Mexico (MX)
Netherlands (NL)
Singapore (SG)South Africa (ZA)Spain (ES)
Tunisia (TN)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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