The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | C | Cardiovascular system | |
| 2 | C08 | Calcium channel blockers | |
| 3 | C08D | Selective calcium channel blockers with direct cardiac effects |
| Code | Title | |
|---|---|---|
| C08DA | Phenylalkylamine derivatives | |
| C08DB | Benzothiazepine derivatives |
| Active Ingredient | Description | |
|---|---|---|
| Diltiazem |
Diltiazem is a calcium antagonist. It restricts the slow channel entry of calcium into the cell and so reduces the liberation of calcium from stores in the sarcoplasmic reticulum. This results in a reduction of the amount of available intracellular calcium reducing myocardial oxygen consumption. |
|
| Verapamil |
Verapamil inhibits the transmembrane influx of calcium ions into the heart and vascular smooth muscle cell. The myocardial oxygen demand is lowered directly as a result of the effect on the energy consuming metabolic processes of the myocardial cell and indirectly due to a reduction of the afterload. Due to its effect on coronary vascular smooth muscle, verapamil enhances myocardial blood flow, even in post‐stenotic areas, and relieves coronary spasms. These properties contribute to the anti‐ischaemic and antianginal efficacy of verapamil in all types of coronary artery disease. |
| Title | Information Source | Document Type | |
|---|---|---|---|
| ADIZEM-XL Prolonged release capsule | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| AKILEN Film-coated tablet | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
| CARDIZEM CD Extended-release capsule | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| ISOPTIN Film‐coated tablet | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
| ISOPTIN Solution for injection / infusion | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
| SECURON Solution for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| SECURON SR Modified-release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| TIAZAC Capsule, ectended release | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| TILDIEM Modified-release tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
