Chemical formula: C₂₄H₂₉NO₃ Molecular mass: 379.492 g/mol PubChem compound: 3152
Donepezil hydrochloride is a specific and reversible inhibitor of acetylcholinesterase, the predominant cholinesterase in the brain. Donepezil hydrochloride is in vitro over 1000 times more potent an inhibitor of this enzyme than of butyrylcholinesterase, an enzyme that is present mainly outside the central nervous system.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N06DA02 | Donepezil | N Nervous system → N06 Psychoanaleptics → N06D Anti-dementia drugs → N06DA Anticholinesterases |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ARICEPT Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ARICEPT Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Donepezil is an active ingredient of these brands:
United States (US)Albania (AL)Australia (AU)Brazil (BR)
Canada (CA)
Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)France (FR)
Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)
Italy (IT)Lithuania (LT)Malta (MT)Mexico (MX)
Netherlands (NL)
Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)
Spain (ES)Tunisia (TN)Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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