Epoetin zeta Other names: Erythropoietin EPO

Therapeutic indications

Epoetin zeta is indicated for:

Anaemia associated with chronic renal failure (CRF)

Population group: only adults (18 years old or older)

Epoetin zeta is indicated for the treatment of symptomatic anaemia associated with chronic renal failure (CRF):

  • in adults on haemodialysis and adult patients on peritoneal dialysis.
  • in adults with renal insufficiency not yet undergoing dialysis for the treatment of severe anaemia of renal origin accompanied by clinical symptoms in patients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Anaemia associated with chemotherapy

Population group: only adults (18 years old or older)

Epoetin zeta is indicated in adults receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient’s general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy) for the treatment of anaemia and reduction of transfusion requirements.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Autologous blood predonation programme

Population group: only adults (18 years old or older)

Epoetin zeta is indicated in adults in a predonation programme to increase the yield of autologous blood. Treatment should only be given to patients with moderate anaemia (haemoglobin [Hb] concentration range between 10 to 13 g/dL [6.2 to 8.1 mmol/L], no iron deficiency) if blood saving procedures are not available or insufficient when the scheduled major elective surgery requires a large volume of blood (4 or more units of blood for females or 5 or more units for males).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Anaemia with risk of primary myelodysplastic syndromes (MDS) who have low serum erythropoietin

Population group: only adults (18 years old or older)

Epoetin zeta is indicated for the treatment of symptomatic anaemia (haemoglobin concentration of ≤10 g/dL) in adults with low- or intermediate-1-risk primary myelodysplastic syndromes (MDS) who have low serum erythropoietin (<200 mU/mL).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Anaemia associated with chronic renal failure (CRF)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Epoetin zeta is indicated for the treatment of symptomatic anaemia associated with chronic renal failure (CRF) in children aged 1 to 18 years on haemodialysis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Epoetin zeta is contraindicated in the following cases:

Uncontrolled hypertension

Hypertensive crisis

Major orthopaedic surgery, coronary, peripheral arterial, cerebral vascular disease, cerebral vascular accident

at least one of
Operation on musculoskeletal system
Coronary arteriosclerosis
Peripheral arterial vascular disease
Cerebrovascular disease
Disorder of carotid artery
CVA - Cerebrovascular accident
Myocardial infarction

Pure red cell aplasia (PRCA)

Antibody mediated acquired pure red cell aplasia caused by erythropoiesis stimulating agent

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