Chemical formula: C₂₂H₂₉FO₄ Molecular mass: 376.462 g/mol PubChem compound: 9878
Fluorometholone is a synthetic corticosteroid (glucocorticoid), a derivative of desoxyprednisolone. It is a member of the group of universally known steroids used for the treatment of eye inflammation. Glucocorticosteroids bind to cytoplasmic receptors and control the synthesis of infection mediators thus damping inflammatory reactions (swelling, fibrin deposition, capillary dilatation, phagocyte migration) and also capillary proliferation, collagen deposition and scarring.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C05AA06 | Fluorometholone | C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AA Corticosteroids |
| D07AB06 | Fluorometholone | D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AB Corticosteroids, moderately potent (group II) |
| D07XB04 | Fluorometholone | D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07X Corticosteroids, other combinations → D07XB Corticosteroids, moderately potent, other combinations |
| D10AA01 | Fluorometholone | D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AA Corticosteroids, combinations for treatment of acne |
| S01BA07 | Fluorometholone | S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BA Corticosteroids, plain |
| S01CB05 | Fluorometholone | S Sensory organs → S01 Ophthalmologicals → S01C Antiinflammatory agents and antiinfectives in combination → S01CB Corticosteroids/antiinfectives/mydriatics in combination |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| FML Eye drops, suspension | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| FLAREX Eye drops, suspension | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Fluorometholone is an active ingredient of these brands:
Canada (CA)
Ecuador (EC)
Finland (FI)France (FR)Hong Kong (HK)
Ireland (IE)Israel (IL)Japan (JP)Lithuania (LT)
Malta (MT)
Mexico (MX)Netherlands (NL)New Zealand (NZ)Romania (RO)Singapore (SG)Spain (ES)
Tunisia (TN)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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