Imatinib

Chemical formula: C₂₉H₃₁N₇O  Molecular mass: 493.603 g/mol  PubChem compound: 5291

Active ingredient description

Imatinib is a protein-tyrosine kinase inhibitor which potently inhibits the Bcr-Abl tyrosine kinase at the in vitro, cellular and in vivo levels.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01EA01 Imatinib L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EA BCR-ABL tyrosine kinase inhibitors
Discover more medicines within L01EA01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
GILVEC Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
GLEEVEC Film coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 152459-95-5
DrugBank Drug: DB00619
KEGG Drug: D01441
PubChem Compound: 5291
RxNorm Ingredient: 282388
SNOMED-CT Concept: 414460008
Imatinib (substance)
UNII Identifier: BKJ8M8G5HI
IMATINIB

Medicines

Imatinib is an active ingredient of these brands:

United States (US)

Albania (AL)

  • IMATIS as IMATINIB MESYLATE
  • NIBIX as IMATINIB MESYLATE

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

  • GLIVEC as IMATINIB MESYLATE
  • NIBIX as IMATINIB MESYLATE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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