Imatinib

Chemical formula: C₂₉H₃₁N₇O  Molecular mass: 493.603 g/mol  PubChem compound: 5291

Therapeutic indications

Imatinib is indicated for:

Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL)

Population group: only adults (18 years old or older)

Imatinib is indicated for the treatment of:

  • adult and paediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) integrated with chemotherapy.
  • adult patients with relapsed or refractory Ph+ ALL as monotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic myeloid leukaemia (CML) Philadelphia chromosome (bcr-abl) positive (Ph+)

Population group: only adults (18 years old or older)

Imatinib is indicated for the treatment of:

  • adult and paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of treatment.
  • adult and paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase or blast crisis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Metastatic malignant gastrointestinal stromal tumours (GIST) with Kit (CD 117) positive

Population group: only adults (18 years old or older)

Imatinib is indicated for:

  • the treatment of adult patients with Kit (CD 117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumours (GIST).
  • the adjuvant treatment of adult patients who are at significant risk of relapse following resection of Kit (CD117)-positive GIST. Patients who have a low or very low risk of recurrence should not receive adjuvant treatment.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Myelodysplastic/myeloproliferative diseases (MDS/MPD) with platelet-derived growth factor receptor (PDGFR) gene re-arrangements

Population group: only adults (18 years old or older)

Imatinib is indicated for the treatment of adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with platelet-derived growth factor receptor (PDGFR) gene re-arrangements.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL) with FIP1L1-PDGFRa rearrangement

Population group: only adults (18 years old or older)

Imatinib is indicated for the treatment of adult patients with advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL) with FIP1L1-PDGFRa rearrangement.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Dermatofibrosarcoma protuberans (DFSP)

Population group: only adults (18 years old or older)

Imatinib is indicated for the treatment of adult patients with unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic myeloid leukaemia (CML) Philadelphia chromosome (bcr-abl) positive (Ph+)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Imatinib is indicated for the treatment of:

  • adult and paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of treatment.
  • adult and paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase or blast crisis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Imatinib is indicated for the treatment of:

  • adult and paediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) integrated with chemotherapy.
  • adult patients with relapsed or refractory Ph+ ALL as monotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

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