Chemical formula: C₈H₁₀IN₃ Molecular mass: 275.09 g/mol PubChem compound: 71184
Iobenguane is similar in structure to the neurotransmitter norepinephrine (NE) and is subject to the same uptake and accumulation pathways as NE. Pheochromocytoma and paraganglioma (PPGL) are tumors of neural crest origin that express high levels of the NE transporter on their cell surfaces. Following intravenous administration, iobenguane ¹³¹I is taken up and accumulates within pheochromocytoma and paraganglioma cells, and radiation resulting from radioactive decay of ¹³¹I causes cell death and tumor necrosis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V10XA02 | Iobenguane (131I) | V Various → V10 Therapeutic radiopharmaceuticals → V10X Other therapeutic radiopharmaceuticals → V10XA Iodine (131I) compounds |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| AZEDRA Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Iobenguane ¹³¹I is an active ingredient of these brands:
United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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