Chemical formula: C₂₀H₂₈O₂ Molecular mass: 300.435 g/mol PubChem compound: 5282379
Isotretinoin is a stereoisomer of all-trans retinoic acid (tretinoin). The exact mechanism of action of isotretinoin has not yet been elucidated in detail, but it has been established that the improvement observed in the clinical picture of severe acne is associated with suppression of sebaceous gland activity and a histologically demonstrated reduction in the size of the sebaceous glands. Furthermore, a dermal anti-inflammatory effect of isotretinoin has been established.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D10AD04 | Isotretinoin | D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne |
| D10BA01 | Isotretinoin | D Dermatologicals → D10 Anti-acne preparations → D10B Anti-acne preparations for systemic use → D10BA Retinoids for treatment of acne |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ISOTRETINOIN Capsules, soft | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ISOTREX Gel | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Isotretinoin is an active ingredient of these brands:
Australia (AU)Austria (AT)Croatia (HR)Ecuador (EC)Estonia (EE)France (FR)Germany (DE)Hong Kong (HK)Ireland (IE)Lithuania (LT)Nigeria (NG)Poland (PL)Romania (RO)Singapore (SG)South Africa (ZA)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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