Chemical formula: C₂₇H₃₆N₂O₅ Molecular mass: 468.594 g/mol PubChem compound: 132999
Ivabradine is a pure heart rate lowering agent, acting by selective and specific inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarisation in the sinus node and regulates heart rate. The cardiac effects are specific to the sinus node with no effect on intra-atrial, atrioventricular or intraventricular conduction times, nor on myocardial contractility or ventricular repolarisation.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C01EB17 | Ivabradine | C Cardiovascular system → C01 Cardiac therapy → C01E Other cardiac preparations → C01EB Other cardiac preparations |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PROCORALAN Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Ivabradine is an active ingredient of these brands:
United States (US)
Australia (AU)
Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Italy (IT)
Japan (JP)
Lithuania (LT)
Malta (MT)
Mexico (MX)
Netherlands (NL)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)Spain (ES)
Tunisia (TN)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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