Larotrectinib

Chemical formula: C₂₁H₂₂F₂N₆O₂  Molecular mass: 428.444 g/mol 

Therapeutic indications

Larotrectinib is indicated for:

Solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion

Population group: only adults (18 - 65 years old)

Larotrectinib as monotherapy is indicated for the treatment of adult and paediatric patients with solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion,

  • who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and
  • who have no satisfactory treatment options.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Larotrectinib as monotherapy is indicated for the treatment of adult and paediatric patients with solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion,

  • who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and
  • who have no satisfactory treatment options.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

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