Chemical formula: C₁₂H₉F₃N₂O₂ Molecular mass: 270.207 g/mol PubChem compound: 3899
Leflunomide is indicated for:
Population group: only adults (18 years old or older)
Leflunomide is indicated for the treatment of adult patients with active rheumatoid arthritis as a “disease-modifying antirheumatic drug” (DMARD).
Recent or concurrent treatment with hepatotoxic or haematotoxic DMARDs (e.g. methotrexate) may result in an increased risk of serious adverse reactions; therefore, the initiation of leflunomide treatment has to be carefully considered regarding these benefit/risk aspects.
Moreover, switching from leflunomide to another DMARD without following the washout procedure may also increase the risk of serious adverse reactions even for a long time after the switching.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only adults (18 years old or older)
Leflunomide is indicated for the treatment of adult patients with active psoriatic arthritis.
Recent or concurrent treatment with hepatotoxic or haematotoxic DMARDs (e.g. methotrexate) may result in an increased risk of serious adverse reactions; therefore, the initiation of leflunomide treatment has to be carefully considered regarding these benefit/risk aspects.
Moreover, switching from leflunomide to another DMARD without following the washout procedure may also increase the risk of serious adverse reactions even for a long time after the switching.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Leflunomide is contraindicated in the following cases:
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