Lomustine Other names: CCNU Chloroethylcyclohexylnitrosourea

Chemical formula: C₉H₁₆ClN₃O₂  Molecular mass: 233.695 g/mol  PubChem compound: 3950

Therapeutic indications

Lomustine is indicated for:

Brain tumours (primary or metastatic)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Intracranial tumour

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Oat cell carcinoma of lung

Population group: only adults (18 years old or older)

Oat cell carcinoma of lung

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Hodgkin's disease

Population group: only adults (18 years old or older)

Hodgkin’s disease (resistant to conventional combination chemotherapy).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Malignant melanoma (metastatic)

Population group: only adults (18 years old or older)

Metastatic malignant melanoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Lomustine is contraindicated in the following cases:

Hypersensitivity to lomustine

Lomustine allergy

Pregnancy

Pregnancy

Lactation

Lactation

Severe bone marrow depression

Bone marrow depression

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Celiac disease

Coeliac disease

Wheat allergy

Allergy to wheat

Yellow fever vaccines

Yellow fever vaccines

Live vaccines

Live organism vaccines

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2019: LOMUSTINE MEDAC Capsule
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