Mefloquine

Chemical formula: C₁₇H₁₆F₆N₂O Molecular mass: 378.312 g/mol PubChem compound: 4046

Therapeutic indications

Mefloquine is indicated for:

Plasmodium falciparum malaria

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Mefloquine is especially indicated for therapy of plasmodium falciparum malaria in which the pathogen has become resistant to other antimalarial agents.

Following treatment of P. vivax malaria with mefloquine, relapse prophylaxis with an 8-amino-quinoline derivative, for example primaquine, should be considered in order to eliminate parasites in the hepatic phase.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

20–25 mg/kg in 2-3 divided doses daily

Malaria chemoprophylaxis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Malaria chemoprophylaxis with Lariam is particularly recommended for travellers to malarious areas in which multiply resistant P. falciparum strains occur.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 mg/kg once weekly

Contraindications

Mefloquine is contraindicated in the following cases:

Depression, generalised anxiety disorder, psychosis, suicide attempts, suicidal ideations, schizophrenia, convulsion

at least one of

Depressive disorder
Generalized anxiety disorder
Psychotic disorder
Suicidal ideation
Schizophrenia
Seizure

Halofantrine

Blackwater fever

Black water fever

Severe hepatic impairment

Hepatic failure stage IV

< Previous: Overview

Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.