Midazolam

Chemical formula: C₁₈H₁₃ClFN₃  Molecular mass: 325.767 g/mol  PubChem compound: 4192

Therapeutic indications

Midazolam is indicated for:

Sedation during minor medical procedures

Population group: only adults (18 - 65 years old)

As intravenous sedative cover before and during minor medical, dental and surgical procedures such as gastroscopy, endoscopy, cystoscopy, bronchoscopy and cardiac catheterisation.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Sedation during minor medical procedures

Population group: only elderly (65 years old or older)

As intravenous sedative cover before and during minor medical, dental and surgical procedures such as gastroscopy, endoscopy, cystoscopy, bronchoscopy and cardiac catheterisation.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Sedation in intensive care

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For sedation by continuous infusion in patients in intensive care.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Induction of anaesthesia

Population group: only adults (18 years old or older)

As an alternative intravenous agent for the induction of anaesthesia in high risk and elderly patients, especially where cardiovascular stability is of particular importance. Induction is more reliable when heavy opiate premedication has been administered or when midazolam is given with a narcotic analgesic such as fentanyl.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Induction of anaesthesia

Population group: only elderly (65 years old or older)

As an alternative intravenous agent for the induction of anaesthesia in high risk and elderly patients, especially where cardiovascular stability is of particular importance. Induction is more reliable when heavy opiate premedication has been administered or when midazolam is given with a narcotic analgesic such as fentanyl.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Induction of anaesthesia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

As an alternative intravenous agent for the induction of anaesthesia in high risk and elderly patients, especially where cardiovascular stability is of particular importance. Induction is more reliable when heavy opiate premedication has been administered or when midazolam is given with a narcotic analgesic such as fentanyl.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Premedication

Population group: only adults (18 - 65 years old)

As an intramuscular premedication for patients with physical status ASA I-IV who are to undergo surgical procedures.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Premedication

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Midazolam is indicated in children from 6 months to 17 years old as premedication before anaesthesia.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Sedation during minor medical procedures

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Midazolam is indicated in children from 6 months to 17 years old, for moderate sedation before a therapeutic or diagnostic procedure.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prolonged, acute, convulsive seizures

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of prolonged, acute, convulsive seizures in infants, toddlers, children and adolescents (from 3 months to <18 years).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Midazolam is contraindicated in the following cases:

Sleep apnoea syndrome

Sleep apnea

Effects on ability to drive and use machines

Effects on ability to drive and use machines

Hypersensitivity to midazolam

Midazolam allergy

Severe respiratory failure, acute respiratory depression

at least one of
Respiratory failure
Decreased respiratory function

Myasthenia Gravis

Myasthenia gravis

Severe hepatic impairment

Hepatic failure stage IV

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