Mupirocin

Chemical formula: C₂₆H₄₄O₉  Molecular mass: 500.622 g/mol  PubChem compound: 446596

Interactions

Mupirocin interacts in the following cases:

Pseudomembranous colitis

Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in patients who develop diarrhoea during or after antibiotic use. Although this is less likely to occur with topically applied mupirocin, if prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further.

Pregnancy

Reproduction studies on mupirocin in animals have revealed no evidence of harm to the foetus. As there is no clinical experience on its use during pregnancy, mupirocin should only be used in pregnancy when the potential benefits outweigh the possible risks of treatment.

Nursing mothers

It is unknown whether mupirocin is excreted in human milk. If a cracked nipple is to be treated, it should be thoroughly washed prior to breast-feeding.

Carcinogenesis, mutagenesis and fertility

Fertility

There are no data on the effects of mupirocin on human fertility. Studies in rats showed no effects on fertility.

Effects on ability to drive and use machines

No adverse effects on the ability to drive or operate machinery have been identified.

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