Nalbuphine

Chemical formula: C₂₁H₂₇NO₄  Molecular mass: 357.443 g/mol  PubChem compound: 5311304

Active ingredient description

Nalbuphine is an opioid with kappa-agonistic and mu-antagonistic properties. Beside the essential agonistic (analgesic) effect nalbuphine has antagonistic effects of about a fourth of nalorfine and ten times of pentazocine.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N02AF02 Nalbuphine N Nervous system → N02 Analgesics → N02A Opioids → N02AF Morphinan derivatives
Discover more medicines within N02AF02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
NUBAIN Solution for injection Health Products and Food Branch (CA) MPI, CA: SPM
NALPAIN Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 20594-83-6
CAS Substance: 23277-43-2
DrugBank Drug: DB00844
KEGG Drug: D08246
PubChem Compound: 5311304
RxNorm Ingredient: 7238
SNOMED-CT Concept: 373539006
Nalbuphine (substance)
UNII Identifier: L2T84IQI2K
NALBUPHINE

Medicines

Nalbuphine is an active ingredient of these brands:

Austria (AT)

  • NUBAIN as NALBUPHINE HYDROCHLORIDE

Brazil (BR)

  • NUBAIN as NALBUPHINE HYDROCHLORIDE

Canada (CA)

  • NUBAIN as NALBUPHINE HYDROCHLORIDE

Estonia (EE)

  • NALPAIN as NALBUPHINE HYDROCHLORIDE

France (FR)

  • NALPAIN as NALBUPHINE HYDROCHLORIDE

Hong Kong (HK)

  • INTAPAN as NALBUPHINE HYDROCHLORIDE

Ireland (IE)

Poland (PL)

  • NALPAIN as NALBUPHINE HYDROCHLORIDE

South Africa (ZA)

  • LANPHI as NALBUPHINE HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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