Chemical formula: C₂₀H₄₀N₃NaO₁₀P Molecular mass: 536.235 g/mol
Pegaptanib is a pegylated modified oligonucleotide that binds with high specificity and affinity to extracellular Vascular Endothelial Growth Factor (VEGF165) inhibiting its activity. VEGF is a secreted protein that induces angiogenesis, vascular permeability and inflammation, all of which are thought to contribute to the progression of the neovascular (wet) form of AMD.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| S01LA03 | Pegaptanib | S Sensory organs → S01 Ophthalmologicals → S01L Ocular vascular disorder agents → S01LA Antineovascularisation agents |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| MACUGEN Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC |
Pegaptanib is an active ingredient of these brands:
United States (US)
Lithuania (LT)
Romania (RO)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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