Chemical formula: C₁₉H₂₄N₄O₂ Molecular mass: 340.42 g/mol PubChem compound: 4735
There is no evidence of the safety of pentamidine isetionate in human pregnancy. A miscarriage within the first trimester of pregnancy has been reported following aerosolised prophylactic administration. Pentamidine isetionate should not be administered to pregnant patients unless considered essential.
The use of pentamidine isetionate is contra-indicated in breast feeding mothers unless considered essential by the physician.
There are no data on the effects of pentamidine on fertility in animals or humans.
Pentamidine has no known effect on the ability to drive and use machines. Considering the risk of dizziness, one should be careful.
Adverse reactions frequency is defined using the following convention: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).
Common: leucopenia, thrombocytopenia, anaemia.
Frequency not known: Hypersensitivity reactions, including anaphylactic reactions and anaphylactic shock, angioedema.
Very common: azotemia
Common: hypoglycaemia, hyperglycaemia, hyperkalaemia, hypocalcaemia, hypomagnesemia.
Common: syncope, dizziness.
Frequency not known: Extremity paraesthesia as well as facial and perioral hypoesthesia have been reported with IV administration of pentamidine, both in children and adults. The cases occurred during or shortly after the IV infusion and resolved after completion or interruption of the infusion.
__Rare: QT interval prolongation, cardiac arrhythmia.
Frequency not known: Torsades de Pointes, bradycardia.
Common: hypotension, flushing.
Common: nausea and vomiting, taste disturbance.
Rare: pancreatitis.
Common: abnormal liver function tests.
Common: rash.
Frequency not known: Stevens-Johnson syndrome.
Very common: acute renal failure, macroscopic haematuria.
Very common: local reactions ranging in severity from discomfort and pain to induration, abscess formation and muscle necrosis.
Frequency not known: rhabdomyolysis has been reported following intramuscular administration.
Frequency not known: Hypersensitivity reactions, including anaphylactic reactions and anaphylactic shock, angioedema.
Frequency not known: hypoglycaemia.
Frequency not known: light-headedness.
Frequency not known: bradycardia.
Frequency not known: hypotension.
Common: local reactions ranging in severity from cough, shortness of breath, wheezing, bronchospasms, particularly in patients with a history of smoking or asthma, which can usually be controlled by prior use of bronchodilators.
Rare: eosinophilic pneumonia.
Frequency not known: pneumothorax in patients presenting a history of Pneumocystis carinii pneumonia.
Common: taste disturbance, nausea.
Frequency not known: acute pancreatitis.
Frequency not known: rash.
Frequency not known: renal insufficiency.
Frequency not known: fever, decrease in appetite, fatigue.
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