Perindopril, Amlodipine and Indapamide

Therapeutic indications

Perindopril, Amlodipine and Indapamide is indicated for:

Essential hypertension

Population group: only adults (18 years old or older)

Perindopril/indapamide/amlodipine combination is indicated as substitution therapy for treatment of essential hypertension, in patients already controlled with perindopril/indapamide fixed dose combination and amlodipine, taken at the same dose level.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 mg/1.25 mg/5 mg, 5 mg/1.25 mg/10 mg, 10 mg/2.5 mg/5 mg or 10 mg/2.5 mg/10 mg of perindopril/indapamide/amlodipine once daily

Contraindications

Perindopril, Amlodipine and Indapamide is contraindicated in the following cases:

Pregnancy

Lactation

Decompensated heart failure

Decompensated cardiac failure

Moderate renal impairment for specific doses

at least one of

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic impairment

Hepatic failure stage IV

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