Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (ACE). Inhibition of ACE results in a reduction of angiotensin II in the plasma, which leads to increased plasma renin activity and reduced secretion of aldosterone. Since ACE inactivates bradykinin, inhibition of ACE also results in an increased activity of circulating and local kallikrein-kinin systems. It is possible that this mechanism contributes to the blood pressure-lowering action of ACE inhibitors. Bisoprolol is a highly beta1-selective-adrenoceptor blocking agent, lacking intrinsic stimulating and relevant membrane stabilising activity. Bisoprolol is generally not to be expected to influence the airway resistance and beta2-mediated metabolic effects.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BX02 | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BX ACE inhibitors, other combinations | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| COSYREL Film-coated tablet | Health Sciences Authority (SG) | MPI, EU: SmPC |
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