Pethidine Other names: Pethidine Pethidine Hydrochloride

Chemical formula: C₁₅H₂₁NO₂  Molecular mass: 247.333 g/mol  PubChem compound: 4058

Therapeutic indications

Pethidine is indicated for:

Moderate to severe pain

Population group: only adults (18 - 65 years old)

Pethidine hydrochloride may be used as an analgesic for the relief of moderate to severe pain including: obstetric analgesia; pre-operative medication and analgesia during anaesthesia; post-operative analgesia.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Moderate to severe pain

Population group: only elderly (65 years old or older)

Pethidine hydrochloride may be used as an analgesic for the relief of moderate to severe pain including: obstetric analgesia; pre-operative medication and analgesia during anaesthesia; post-operative analgesia.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Moderate to severe pain

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Pethidine hydrochloride may be used as an analgesic for the relief of moderate to severe pain including: obstetric analgesia; pre-operative medication and analgesia during anaesthesia; post-operative analgesia.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Pethidine is contraindicated in the following cases:

Coma, respiratory depression, obstructive airways disease, acute asthma

at least one of
Coma
Decreased respiratory function
Obstructive emphysema
Chronic obstructive lung disease
Respiratory obstruction
Exacerbation of asthma

Diabetic acidosis

Diabetic ketoacidosis

Pheochromocytoma

Phaeochromocytoma

Acute alcoholism, delirium tremens, convulsive disorders, paralytic ileus

at least one of
Alcohol intoxication
Alcohol withdrawal delirium
Seizure disorder
Paralytic ileus

Respiratory insufficiency, head injuries, raised intracranial pressure, severe hepatic impairment, severe renal impairment

at least one of
Respiratory insufficiency
Injury of head
Raised intracranial pressure
Hepatic failure stage IV

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Monoamine oxidase inhibitors, moclobemide

at least one of
Monoamine oxidase inhibitors (MAOIs)
Moclobemide

Hypersensitivity to pethidine

Pethidine allergy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2019: PETHIDINE Tablet
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