Chemical formula: KI Molecular mass: 166.003 g/mol PubChem compound: 4875
Potassium iodide interacts in the following cases:
Potassium salts given concomitantly with potassium-sparing diuretics such as amiloride or triamterene or aldosterone antagonists may cause hyperkalaemia.
Several drugs, such as captopril and enalapril can cause hyperkalaemia and this effect may be enhanced if potassium iodide is also administered.
The effect of quinidine on the heart is increased by increased plasma concentration of potassium.
The risk of iodine induced hyperthyroidism may be increased in patients with asymptomatic nodular goitre or latent Graves' disease, who are not under medical care.
Patients with thyrotoxicosis treated medically, or patients with a past history of thyrotoxicosis treated medically who are now off treatment and apparently in remission, may be at risk.
Repeated administration of iodine during pregnancy may suppress foetal thyroid function. Reproductive toxicity has been established in animal studies. Therefore, pregnant women should not receive more than one dose. If iodine is taken in late pregnancy it is recommended to monitor the thyroid function of the newborn.
Iodine is being excreted into breast milk in large amounts, but these amounts are too small to protect the baby sufficiently. Thus the baby has to be given iodine as well. If the intake during breast-feeding is necessary, breast-feeding women should not receive more than one dose.
No human data on the effect of active substance potassium iodide on fertility are available. There is no preclinical information available on the effect of the active substance potassium iodide on mating or fertility.
Not relevant.
Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1 000 to <1/100), Rare (≥1/10 000 to <1/1 000), Very rare (<1/10 000), Not known (cannot be estimated from the available data).
Not known: Hypersensitivity reactions such as swolen salivary glands, headache, bronchospasm and gastro-intestinal disturbances can be mild or severe and may be dose dependent.
Not known: Iodine-induced autoimmunity (Grave’s and Hashimoto type), toxic nodular goitre and iodine-induced transient hyper- or hypothyroidism have been reported as side effects of iodine therapy.
An overactive thyroid gland, thyroiditis, and an enlarged thyroid gland with or without development or myxoedema have also been reported.
Not known: Continued administration may lead to mental depression, nervousness, sexual impotence and insomnia.
Not known: sialadenitis, gastrointestinal disturbances
Rare: temporary skin rash
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