Prochlorperazine

Chemical formula: C₂₀H₂₄ClN₃S  Molecular mass: 373.943 g/mol  PubChem compound: 4917

Active ingredient description

Prochlorperazine belongs to the phenothiazine group. Prochlorperazine has a wide range of activity arising from its depressant actions on the CNS and its alpha-adrenergic blocking and weaker anti-muscarinic properties. It inhibits dopamine and prolactin-release-inhibitory factor, thus stimulating the release of prolactin.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N05AB04 Prochlorperazine N Nervous system → N05 Psycholeptics → N05A Antipsychotics → N05AB Phenothiazines with piperazine structure
Discover more medicines within N05AB04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
PROCHLORPERAZINE Tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PROCHLORPERAZINE Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 58-38-8
DrugBank Drug: DB00433
KEGG Drug: D00493
PubChem Compound: 4917
RxNorm Ingredient: 8704
SNOMED-CT Concept: 372853006
Prochlorperazine (substance)
UNII Identifier: YHP6YLT61T
PROCHLORPERAZINE

Medicines

Prochlorperazine is an active ingredient of these brands:

United States (US)

Australia (AU)

Cyprus (CY)

  • NAUTISOL as PROCHLORPERAZINE DIMETHANESULFONATE
  • STEMETIL as PROCHLORPERAZINE MALEATE
  • STEREMAL as PROCHLORPERAZINE MALEATE

Estonia (EE)

Finland (FI)

Hong Kong (HK)

  • NAUTISOL as PROCHLORPERAZINE DIMETHANESULFONATE
  • PEMAZIL as PROCHLORPERAZINE MALEATE
  • PERATIL as PROCHLORPERAZINE MALEATE
  • PROTIL as PROCHLORPERAZINE MALEATE
  • SERATIL as PROCHLORPERAZINE MALEATE
  • STEMETIL as PROCHLORPERAZINE MALEATE

Ireland (IE)

Japan (JP)

  • NOVAMIN as PROCHLORPERAZINE MALEATE

Malta (MT)

New Zealand (NZ)

Romania (RO)

Singapore (SG)

South Africa (ZA)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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