ATC Group: N05AB Phenothiazines with piperazine structure

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of N05AB in the ATC hierarchy

Level Code Title
1 N Nervous system
2 N05 Psycholeptics
3 N05A Antipsychotics
4 N05AB Phenothiazines with piperazine structure

Group N05AB contents

Code Title
N05AB01 Dixyrazine
N05AB02 Fluphenazine
N05AB03 Perphenazine
N05AB04 Prochlorperazine
N05AB05 Thiopropazate
N05AB06 Trifluoperazine
N05AB07 Acetophenazine
N05AB08 Thioproperazine
N05AB09 Butaperazine
N05AB10 Perazine

Active ingredients in N05AB

Active Ingredient Description
Fluphenazine

Fluphenazine is an ester of the potent neuroleptic fluphenazine, a phenothiazine derivative of the piperazine type. The ester is slowly absorbed from the intramuscular site of injection and is then hydrolysed in the plasma to the active therapeutic agent, fluphenazine. It is used for the treatment and maintenance of schizophrenic patients and those with paranoid psychoses.

Perphenazine

Perphenazine is a depressant which blocks dopamine receptors in the central nervous system. It binds to dopamine D1 and D2 receptors and inhibits their activity. Its antiemetic action is mainly due to the inhibition of D2 receptors in the center of the vomiting. Perphenazine also binds to alpha adrenergic receptors and in conjunction with G proteins activate the phosphatidylinositol-calcium system.

Prochlorperazine

Prochlorperazine belongs to the phenothiazine group. Prochlorperazine has a wide range of activity arising from its depressant actions on the CNS and its alpha-adrenergic blocking and weaker anti-muscarinic properties. It inhibits dopamine and prolactin-release-inhibitory factor, thus stimulating the release of prolactin.

Trifluoperazine

Trifluoperazine is one of the phenothiazine class of compounds and as such has many pharmacodynamic effects which relate to its therapeutic actions and side effects. The most notable action of phenothiazines is antagonism at dopamine receptors in the CNS.

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