Saquinavir

Chemical formula: C₃₈H₅₀N₆O₅  Molecular mass: 670.841 g/mol  PubChem compound: 441243

Therapeutic indications

Saquinavir is indicated for:

HIV-1 infection

Population group: only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Saquinavir is indicated for the treatment of HIV-1 infected adult patients. Saquinavir should only be given in combination with ritonavir and other antiretroviral medicinal products.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Saquinavir is contraindicated in the following cases:

Decompensated liver disease

Hepatic insufficiency

Congenital or documented acquired QT prolongation

at least one of
Long QT syndrome
Prolonged QT interval

Hypokalemia

Hypokalemia

Bradycardia

Bradycardia

Heart failure

Cardiac failure

Arrhythmias

Arrhythmia

Drugs that prolong the QT and/or PR interval

at least one of
Drugs prolonging QT interval
Drugs that induce PR prolongation

Rilpivirine

Rilpivirine

Lopinavir

Lopinavir

Alfuzosin

Alfuzosin

Bepridil, lidocaine (systemic), quinidine, hydroquinidine

at least one of
Bepridil
Lidocaine
Quinidine
Hydroquinidine

Amiodarone, flecainide, propafenone

at least one of
Amiodarone
Flecainide
Propafenone

Dofetilide

Dofetilide

Ibutilide

Ibutilide

Tricyclic antidepressants

Maprotiline

Maprotiline

Trazodone

Trazodone

Terfenadine, astemizole

at least one of
Terfenadine
Astemizole

Mizolastine

Mizolastine

Clarithromycin

Clarithromycin

Erythromycin

Erythromycin

Halofantrine, pentamidine, sparfloxacin

at least one of
Halofantrine
Pentamidine
Sparfloxacin

Rifampicin

Rifampicin

Lurasidone

Lurasidone

Quetiapine

Quetiapine

Pimozide

Pimozide

Clozapine, haloperidol, chlorpromazine, mesoridazine, phenothiazines, sertindole, sultopride, thioridazine, ziprasidone

at least one of
Clozapine
Haloperidol
Chlorpromazine
Mesoridazine
Phenothiazines
Sertindole
Sultopride
Thioridazine
Ziprasidone

Midazolam

Midazolam

Triazolam

Triazolam

Simvastatin, lovastatin

at least one of
Simvastatin
Lovastatin

Tacrolimus

Tacrolimus

Methadone

Methadone

Sildenafil

Sildenafil

Vardenafil

Vardenafil

Tadalafil

Tadalafil

Tyrosine kinase inhibitors

Protein kinase inhibitors

Ergot alkaloids

at least one of
Ergot alkaloids
Ergot alkaloids
Ergot alkaloids

CYP3A4 substrates

CYP3A4 substrates

Cisapride

Cisapride

Diphemanil

Diphemanil

Vincamine

Vincamine

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2018: INVIRASE Film-coated tablet
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