Spironolactone
Chemical formula: C₂₄H₃₂O₄S Molecular mass: 416.573 g/mol PubChem compound: 5833
Active ingredient description
Spironolactone, as a competitive aldosterone antagonist, increases sodium excretion whilst reducing potassium loss at the distal renal tubule. It has a gradual and prolonged action.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| C03DA01 | Spironolactone | C Cardiovascular system → C03 Diuretics → C03D Potassium-sparing agents → C03DA Aldosterone antagonists |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| ALDACTONE Film-coated tablet | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Medicines
Spironolactone is an active ingredient of these brands:
Australia (AU)Austria (AT)
Brazil (BR)
Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)Estonia (EE)
Finland (FI)France (FR)
Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Lithuania (LT)Malta (MT)Mexico (MX)
New Zealand (NZ)Nigeria (NG)Poland (PL)Romania (RO)
Singapore (SG)South Africa (ZA)Spain (ES)
Tunisia (TN)
Turkey (TR)
United Kingdom (UK)
United States (US)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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