Chemical formula: C₂₆H₂₅ClN₂O₃ Molecular mass: 448.941 g/mol PubChem compound: 443894
Tolvaptan is a selective vasopressin V2-receptor antagonist that specifically blocks the binding of arginine vasopressin (AVP) at the V2-receptor of the distal portions of the nephron. Tolvaptan affinity for the human V2-receptor is 1.8 times that of native AVP.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C03XA01 | Tolvaptan | C Cardiovascular system → C03 Diuretics → C03X Other diuretics → C03XA Vasopressin antagonists |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SAMSCA Tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| JINARC Tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Tolvaptan is an active ingredient of these brands:
Australia (AU)Netherlands (NL)New Zealand (NZ)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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