Chemical formula: C₂₃H₂₃N₃O₅ Molecular mass: 421.446 g/mol PubChem compound: 60700
Topotecan involves the inhibition of topoisomerase-I, an enzyme intimately involved in DNA replication.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01CE01 | Topotecan | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01C Plant alkaloids and other natural products → L01CE Topoisomerase 1 (TOP1) inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| HYCAMTIN Hard capsule | European Medicines Agency (EU) | MPI, EU: SmPC | |
| HYCAMTIN Powder for concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Topotecan is an active ingredient of these brands:
United States (US)
Australia (AU)
Austria (AT)
Brazil (BR)Croatia (HR)
Cyprus (CY)
Estonia (EE)
Finland (FI)
France (FR)
Ireland (IE)
Israel (IL)
Italy (IT)
Japan (JP)
Lithuania (LT)
Netherlands (NL)
Poland (PL)
Romania (RO)
South Africa (ZA)
Spain (ES)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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